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Postdoctoral Fellow

Department: Hadlock
Location: Seattle, WA

The Hadlock lab at the Institute for Systems Biology (ISB) in Seattle, WA is seeking a Postdoctoral Fellow to join our interdisciplinary team, advancing research on clinical data in systems biology. Our lab focuses on two areas of investigation: risk modeling for clinical decision support and improved patient outcomes, and new data science approaches to accelerate biomedical discovery. We have rare access to one of the largest collections of comprehensive electronic health records (EHRs) in the world, with longitudinal data for over 4,000,000 patients from 50 hospitals across seven states. We also work with high-fidelity data from prospective studies that combine genomics, imaging, health-related social needs, and patient-reported outcomes. Our team collaborates with computer scientists, data scientists, systems biologists and physicians across the country. Current projects include early risk modeling for sepsis, biomarkers in adolescent behavioral health, and applications of domain-agnostic similarity metrics on semi-structured EHR data. Our lab acts as a catalyst for high-impact projects, and we offer the data, tools, support and flexibility needed for members to make rapid progress on novel research. This position offers significant opportunities for growth and career advancement.

Responsibilities include:

  • Pursuing your own research in collaboration with lab team members and external partners

  • Designing and conducting rigorous experiments to evaluate clinical models of complex biomedical systems

  • Analyzing large collections of Electronic Health Records (EHRs) or data from longitudinal clinical studies

  • Developing or applying machine learning and/or biostatistics to detect patterns that can improve clinical decision support and accelerate biomedical discovery

  • Submitting results for publication

  • Writing or contributing to research proposals

  • Participating in collaborative team projects with research, healthcare and industry partners


  • Applicants should hold (or shortly be awarded) a PhD or MD and have expertise in one of the following:

    • Data Science, Computer Science, Applied Mathematics, Statistics, Bioinformatics, or Medical Informatics

  • Experience with collaborative software engineering projects.

  • Experience with at least one of the following:

    • Machine learning: supervised and unsupervised

    • Medical informatics, bioinformatics, epidemiology or clinical trials

    • Research on a specific area of wellness, injury or disease

    • Clinical patient care and electronic health records

  • Excellent organization, prioritization and communication skills

Preferred candidates will also have experience with at least one of the following:

  • Published, peer-reviewed articles, or experience contributing to papers submitted for publication

  • Semantic interoperability, ontologies, knowledge bases, graph theory

  • Natural language processing (NLP)

  • Cloud computing and big data skills, particularly Spark and HDFS

ISB is an EOE (M/F/disabled/veteran status) employer.

Please provide a CV, cover letter, and contact information for two references to be considered for this position.

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